In the autumn of 2014, my M-spike and related protein numbers began creeping up, even after switching from nightly oral doses of Revlimid/dex to Pomalyst/dex. So in late November, my oncologist persuaded me to enter a clinical trial involving experimental doses of Kyprolis, along with twice the amount of dex I’d been taking for years. This got quite effective results right away, along with the side effects you’d expect from doubling your intake of dex. (I did not enter any police blotters, but it was a close thing.)
But in August of this year, the steadily renewed rise in blood test numbers could not be denied. (M-spike currently stands at 1.6. It was 2.7 when the clinical trial began, and 0.4 at its lowest point.) The clinical trial was halted and I am now taking Cytoxan (note the “tox” in there, no joke), along with the same doses of Kyprolis/dex as in past several months. As is so frequently the case, we are now in wait-and-see mode. Catch me in about a month.